Urine test may be as effective as the smear test and prevent cervical cancer

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Urine testing may be as effective as the smear test at preventing cervical cancer, according to new research by University of Manchester scientists.

Cervical cancer begins when healthy cells acquire a genetic change (mutation) that causes them to turn into abnormal cells.

Healthy cells grow and multiply at a set rate, eventually dying at a set time. Cancer cells grow and multiply out of control, and they don’t die.

The accumulating abnormal cells form a mass (tumor).

Cancer cells invade nearby tissues and can break off from a tumor to spread (metastasize) elsewhere in the body.

It isn’t clear what causes cervical cancer, but it’s certain that HPV plays a role.

HPV is very common, and most women with the virus never develop cervical cancer. This means other factors – such as your environment or your lifestyle choices – also determine whether you’ll develop cervical cancer.

Types of cervical cancer

The type of cervical cancer that you have helps determine your prognosis and treatment. The main types of cervical cancer are:

  • Squamous cell carcinoma. This type of cervical cancer begins in the thin, flat cells (squamous cells) lining the outer part of the cervix, which projects into the vagina. Most cervical cancers are squamous cell carcinomas.
  • Adenocarcinoma. This type of cervical cancer begins in the column-shaped glandular cells that line the cervical canal.

Sometimes, both types of cells are involved in cervical cancer. Very rarely, cancer occurs in other cells in the cervix.

Risk factors

Risk factors for cervical cancer include:

  • Many sexual partners. The greater your number of sexual partners — and the greater your partner’s number of sexual partners — the greater your chance of acquiring HPV.
  • Early sexual activity. Having sex at an early age increases your risk of HPV.
  • Other sexually transmitted infections (STIs). Having other STIs — such as chlamydia, gonorrhea, syphilis and HIV/AIDS — increases your risk of HPV.
  • A weak immune system. You may be more likely to develop cervical cancer if your immune system is weakened by another health condition and you have HPV.
  • Smoking. Smoking is associated with squamous cell cervical cancer.

Prevention

To reduce your risk of cervical cancer:

  • Get vaccinated against HPV. Vaccination is available for girls and women ages 9 to 26. The vaccine is most effective if given to girls before they become sexually active.
  • Have routine Pap tests. Pap tests can detect precancerous conditions of the cervix, so they can be monitored or treated in order to prevent cervical cancer. Most medical organizations suggest women begin routine Pap tests at age 21 and repeat them every few years.
  • Practice safe sex. Using a condom, having fewer sexual partners and delaying intercourse may reduce your risk of cervical cancer.
  • Don’t smoke.

The study, led by Dr. Emma Crosbie and published in BMJ Open, found that urine testing was just as good as the cervical smear at picking up high-risk human papillomavirus (HPV), the virus that causes cervical cancer.

The research team say a urine test could help increase the numbers of women who are screened for cervical cancer, which affects more than 3,000 women every year in the UK.

The research was supported by the Manchester NIHR Biomedical Research Centre.

Urine testing could also have a role in the developing world, where cervical cancer is up to 15 times more common and smear testing largely non-existent.

The NHS cervical screening programme tests for so called ‘high-risk’ types of human papillomavirus (HPV) and the health of the cells of the cervix in women who test high-risk HPV positive.

Around one in 20 women show abnormal changes which might go on to become cancer and are referred for colposcopy, where the cervix is examined under magnification, allowing abnormal areas to be seen, sampled and treated, before they ever cause cancer.

According to the team, cervical smear samples, self-collected vaginal samples and urine samples are all effective at picking up high risk HPV infection.

Cervical cancer is most common in women aged 30 to 35 years.

But the precancerous stage is detectable in the five to 10 years before this, when up to a third of women fail to attend for their smear test.

“We’re really very excited by this study, which we think has the potential to significantly increase participation rates for cervical cancer screening in a key demographic group,” said Dr. Emma Crosbie.

“Many younger women avoid the NHS cervical cancer screening programme because they find it embarrassing or uncomfortable, particularly if they have gynaecological conditions like endometriosis.”

She added: “Campaigns to encourage women to attend cervical screening have helped.

The brilliant campaign by the late Jade Goody increased numbers attendance by around 400,000 women.

“But sadly, the effects aren’t long lasting and participation rates tend to fall back after a while. We clearly need a more sustainable solution.”

Of the 100 or so types of HPV, some are linked to cervical cancer, and some are linked to other conditions, like genital warts.

Most cervical cancers are caused by high-risk types HPV-16 and HPV-18.

104 women attending the colposcopy clinic at St Mary’s Hospital, Manchester participated in the study and were screened using two brands of HPV testing kits.

Around two-thirds of the women tested positive for any high-risk HPV type, and a third for HPV-16 or HPV-18.

From the total, 18 women had pre-cancerous changes to the cervix that needed treatment.

With the Roche HPV testing kit, urine, vaginal self samples and cervical smears picked up 15 of these.

With the Abbott HPV testing kit, urine picked up 15 of these and vaginal self samples and cervical smears picked up 16.

Dr. Crosbie said: “These results provide exciting proof of principle that urine HPV testing can pick up cervical pre-cancer cells, but we need to trial it on a greater number of women before it can be used in the NHS. We hope that is going to happen soon.

“Urine is very simple to collect and most hospitals in the developed and developing world have access to the lab equipment to process and test the samples.

“Let us hope this is a new chapter in our fight against cervical cancer, a devastating and pernicious disease.”

Journal information: BMJ Open
Provided by University of Manchester

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