Shortening the duration of treatment with Herceptin for breast cancer patients does not increase the risk of their cancer returning

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A new study co-led by the University of Warwick Clinical Trials Unit has shown that shortening the duration of a therapy for breast cancer patients does not increase the risk of their cancer returning.

The majority of clinical trials in cancer assess either new treatments or additional treatments to the current standard of care.

However equally important questions for patients and healthcare teams concern reduction in the length of treatments and attendant toxicities and whether this can be achieved without any worsening of outcomes.

Clinical trial results published in The Lancet today (6 June) show that women treated with 6 months of Herceptin for HER2 positive early breast cancer did as well in terms of their risk of breast cancer returning as those getting the currently conventional 12 months treatment.

Six months also significantly reduced treatment related side effects, including heart problems.


Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) is an aggressive disease that makes up approximately 20% of all invasive BC [12].

Early stage BC (EBC) describes disease that is detected in the breast and nearby lymph nodes but has not spread to distant areas of the body [3]

Recommended treatment of EBC is a multi-step approach that often includes neoadjuvant therapy, surgery, and adjuvant therapy [46].

Therapy for HER2+ EBC should be based on a patient’s predicted sensitivity to treatments, underlying comorbidities, likelihood of benefit, and risk of relapse [46].

The development of HER2-targeted therapies has revolutionized the treatment of HER2+ BC that was previously associated with high relapse and mortality rates.

Current guidelines suggest that HER2+ EBC patients should receive chemotherapy and anti-HER2 agents, such as originator trastuzumab (Herceptin®; H) [467].

As an antibody-targeted therapy, H binds to the extracellular domain IV of HER2, thereby inhibiting downstream cell signaling implicated in cell proliferation, motility, adhesion, and survival [8].

Initially approved by all major regulatory bodies for the treatment of HER2+ metastatic breast cancer (MBC) [912], approved use of H was expanded to HER2+ EBC in 2006 [1315].

Clinical trials in HER2+ EBC and MBC have established that treatment with H/chemotherapy increases disease-free and overall survival (OS) compared with chemotherapy alone [1620].

Concomitant administration of anthracyclines with H can produce cardiotoxic effects, so non-anthracycline-containing regimens may be beneficial for some patients [52122]. A sequential regimen of anthracyclines and H/taxanes is appropriate for most patients [45]. H for 1 year administered with an acceptable chemotherapy regimen is the recommended standard of care for EBC [46].

The efficacy of H for the treatment of HER2+ EBC has been demonstrated in phase II and phase III clinical trials; however, an assessment of the accumulation of publicly available evidence over time has not been made.


The PERSEPHONE trial, a £2.6 million study funded by the NIHR with translational research funded by Cancer Research UK, recruited over 4,000 women with HER2-positive early-stage breast cancer.

It compared a six month course of Herceptin with the current standard of twelve months to see whether the shorter treatment was similar to or no worse than the longer treatment.

This is the largest trial of its kind examining the impact of shortening the duration of Herceptin

The trial, led by a team from the University of Cambridge and the Clinical Trials Unit at the University of Warwick, involved 4088 women and is larger than any previous study in this field.

It found that 89.4% of patients taking six months treatment were free of breast cancer after four years compared with 89.8% of patients taking treatment for twelve months.

These results show that women who took Herceptin for six months fared no worse than patients who had standard 12 months treatment in terms of breast cancer returning.

In addition, only 3% of women in the six month arm had to stop taking the drug because of heart problems compared with 8% in the 12 month arm.

This trial mapped onto standard practice in the NHS where both chemotherapy and Herceptin are given before or after surgery.

Herceptin has been a major breakthrough, prolonging and saving the lives of women with breast cancers that carry the HER2 receptor on the surface of their cancer cells. Around 15 out of every 100 women with early breast cancers have HER2 positive disease.

Herceptin is a targeted therapy that works by attaching to the HER2 receptors preventing the cancer cells from growing and dividing.

Based on clinical trials a twelve month treatment course was adopted as standard with a requirement for 18 three-weekly injections.

However, a further clinical study, the FinHer trial hinted that a shorter duration might be as effective, significantly reducing side effects and cost both to patients and to healthcare systems.

The NIHR therefore funded this study to compare the standard 12 months of therapy with a shorter 6 month course.

Professor Janet Dunn who led the trial at Warwick Clinical Trials Unit said:

“The NIHR is a great funder for these types of trials as they ultimately refine treatment for patients with the maximum patient benefit ensured.

Data collected on the patient reported experiences confirm the tough time patients have going through treatment and the impact any treatment has on their longer term quality of life.”

Lead study author Professor Helena Earl, Professor of Clinical Cancer Medicine, University of Cambridge and Cancer Research UK Cambridge Centre said “We would like to thank the 4088 patients who took part in our study and the tireless efforts and dedication of the trial teams at both Warwick and Cambridge.

The trial would not have been possible without support from the NHS Clinical Research Network for the 152 teams at centres throughout the UK who recruited patients.

In addition, the PERSEPHONE trials team has benefited enormously from an invaluable partnership with patient advocates throughout the study.

“The trial included patients who were receiving or going to receive Herceptin as standard in the NHS for HER2 positive breast cancer.

The result indicates there are a large number of patients where a reduced Herceptin treatment duration of six months provides a similar benefit to 12 months without the risk of additional side effects.

This data can now be added to all existing data on adjuvant Herceptin to be scrutinized by the wider breast cancer community for consideration of changes to practice.

The study does however also suggest that there may be groups where the longer duration is needed to achieve maximum benefit.

Women currently taking the medication should not change their treatment without seeking advice from their doctor.

There is research to be done to define more precisely women who can reduce their treatment duration.

We are poised to do important translational research analysing blood and tissue samples collected within the trial to look for biomarkers to identify subgroups where shorter or longer durations might be tailored.”

The trial has also collected qualitative research data on patient reported experiences on Herceptin.

Common side effects reported in up to a third of women are aches/pains and fatigue with significant effects on daily functioning and quality of life.

Cost savings for 6 months Herceptin compared with 12 months were presented at the ESMO conference in October 2018, and have been estimated at £9,699 per patient. Detailed cost effectiveness analysis including a life-time model, subgroup analyses and a societal cost analysis are underway.

Given that HER2+ breast cancer represents a significant global burden of the disease, 6 months adjuvant treatment would translate into potential global savings of hundreds of millions of dollars annually.

Worldwide this will have huge impact in middle and low income countries since it will facilitate Herceptin treatment (a World Health Organisation designated essential medicine) for many more women with HER2 positive early breast cancer.

Professor Charles Swanton, Cancer Research UK’s chief clinician, said: “Cancer Research UK’s work paved the way for the development of Herceptin, which has saved the lives of many thousands of women with breast cancer.

But despite years of research, we haven’t been able to establish the optimal duration of Herceptin treatment, either to delay cancer coming back or to cure patients with early HER2 positive breast cancer following surgery.

“These eagerly anticipated results give the breast cancer research community an opportunity to reassess how long to give this targeted therapy to patients to see them living longer and with a better quality of life.

“The important next steps are to work out which patients can stop Herceptin at 6 months and which need extended therapy.”

Maggie Wilcox, President of Independent Cancer patients Voice (ICPV) who is the patient lead for the PERSEPHONE trial, said: “I am delighted to have been part of this landmark trial which is an important step to reduce the length of treatment whilst not changing effectiveness.

Most trials add novel treatments to standard practice whilst this has set out to reduce duration of Herceptin.

The collection of the patient reported experiences throughout the trial will greatly inform future practice and benefit patients. ICPV is working with the Persephone team to help disseminate these exciting results.”

The results of the trial, PERSEPHONE, published in The Lancet today were presented at the June, 2018 ASCO Annual Meeting in Chicago, The full report, which will include analysis to determine the impact of treatment length on quality of life with patient reported experiences and a detailed cost effectiveness analysis, will be published in the NIHR journals library.

More information:The Lancet (2019). DOI: 10.1016/S0140-6736(19)30650-6

Journal information: The Lancet
Provided by University of Warwick

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