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5′-Adenosine monophosphate-activated protein kinase (AMPK) stands as a pivotal serine/threonine kinase, evolutionarily conserved to maintain cellular energy homeostasis. Its regulatory role spans across various physiological and metabolic processes, making it a crucial determinant in aging and longevity.
The dysregulation...
La pandemia globale della malattia da coronavirus (COVID-19) ha posto sfide senza precedenti alla salute pubblica e al benessere socioeconomico (1–3). La capacità del virus di manipolare i meccanismi di difesa cellulare e di eludere la risposta dell'interferone ha stimolato...
The global coronavirus disease (COVID-19) pandemic has posed unprecedented challenges to public health and socio-economic well-being (1–3). The virus's ability to manipulate cellular defense mechanisms and evade the interferon response has prompted intense research into potential therapeutic targets (4,...
In the realm of medical, neuroscience, psychology, and educational research, the efficacy of various treatments, including drugs, cognitive training, biofeedback, and neurostimulation, has been under rigorous scrutiny. However, the diverse findings in these fields have led to growing skepticism...
Polydrug use, the concurrent use of multiple substances, is prevalent among individuals with opioid use disorders (OUD) and has been associated with worsened health outcomes (Compton et al., 2021). Cannabis, in particular, is frequently used by those with OUD,...
Aging is a complex and multifactorial process characterized by the gradual accumulation of molecular damage, leading to age-related frailty, disability, disease, and eventual mortality. Macrophages, essential components of the immune system, play crucial roles in tissue development, homeostasis maintenance,...
The profound bond between humans and their pets is a well-established aspect of the human experience, contributing positively to the welfare of both parties involved. The strength of this attachment bond, however, plays a pivotal role in shaping the...
Il pinostrobin (C16H14O4) è un composto flavonoide derivato da erbe tradizionali cinesi come le foglie di Carya cathayensis, Boesenbergia rotunda e propoli. Con un peso molecolare di 270,28 dalton, la pinostrobina presenta un'ampia gamma di effetti farmacologici, che la rendono un...
Emotional eating, characterized by the excessive consumption of comfort foods in response to negative emotional valence rather than physical hunger, has been a subject of scientific inquiry due to its impact on individuals exposed to life-threatening events. This phenomenon...
Pinostrobin (C16H14O4) is a flavonoid compound derived from traditional Chinese herbs such as Carya cathayensis leaves, Boesenbergia rotunda, and propolis. With a molecular weight of 270.28 daltons, pinostrobin exhibits a wide range of pharmacological effects, making it a potential...
Glaucoma, a leading cause of irreversible blindness globally, affects a staggering 80 million diagnosed patients, with an additional significant number undiagnosed. The hallmark of glaucoma is the progressive dysfunction and degeneration of retinal ganglion cells (RGCs) and their axons,...
The global impact of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached unprecedented levels. As of October 7, 2023, the World Health Organization (WHO) reported over 700 million confirmed cases and...
Caffeine, a widely consumed psychostimulant, has long been recognized for its impact on adenosine receptors, particularly as a competitive antagonist of the A1 and A2A subtypes. The intricate interplay between caffeine and long-term potentiation (LTP) has been a subject...
An ancient Chinese proverb posits, "Without copulation, no population" (Malmnäs, 1973). Although not universally applicable, this maxim holds true for species with internal fertilization. This article explores the intricate relationship between copulation and reproduction, delving into the realms of...
The COVID-19 pandemic has left an indelible mark on global public health, with far-reaching consequences that continue to affect various aspects of healthcare.
Despite the official declaration of the pandemic's end, new cases of COVID-19 persist, prompting a sustained effort...
