Eosinophils may be used to eliminate malignant colon cancer cells

Human cancer cells with nuclei (specifically the DNA) stained blue. The central and right-most cell are in interphase, so the entire nuclei are labeled. The cell on the left is going through mitosis and its DNA has condensed. (TenOfAllTrades/Wikipedia)

Researchers at Tel Aviv University say that their new study has shown that eosinophils — white blood cells that are responsible for chronic asthma and modern allergies — may be used to eliminate malignant colon cancer cells.

The research was led by Prof. Ariel Munitz of the Department of Microbiology and Clinical Immunology at TAU’s Sackler School of Medicine and conducted by TAU doctoral student Hadar Reichman in collaboration with colleagues in Tel Aviv Medical Center’s Gastroenterology Department.

It was published in Cancer Immunology Research on January 21.

“Eosinophils are white blood cells that secrete powerfully destructive proteins,” Munitz said in a statement announcing the study.

“They may have played an evolutionary role in combating parasites.

But now that most people, particularly in the West, enjoy good hygiene and few parasites, the eosinophils have become destructive agents, causing allergies and asthma.

“Our new research theorized that since eosinophils are capable of killing parasites and can cause damage in the lungs of asthma patients, they might play a role in cancer treatment and would be able to kill tumor cells.”

The largest reservoir of eosinophils is situated in the digestive system, so the researchers decided to test their theories initially on colon cancer.

In the first stage of their study, the researchers chose samples from tumors of 275 patients, to determine the number of eosinophils in a tumor as compared with the stage and severity of the disease.

“We found that the higher the number of eosinophils in the tumor, the less severe the disease, which represents a clear correlation,” said Munitz.

The researchers subsequently tested their hypotheses in various mouse models of colorectal cancer.

They discovered that eosinophils displayed potent anti-tumor activities and could directly kill tumor cells.

“We also found that when eosinophils were activated by a protein called IFN-gamma, they induced an even greater tumor-killing response,” says Prof. Munitz.

The fact that eosinophils represent a distinct weapon in fighting tumor cells “opens new avenues for treatment of cancer,” the statement said, either by encouraging eosinophils to unleash their robust anti-tumor response, or by combining treatments to harness the potent forces of both eosinophils and cytotoxic T-cells, which also have the ability to kill cancer.

“We have discovered a new target for immunotherapy for cancer patients — the eosinophils,” Munitz said.

“We hope that our research will serve as a foundation for drug development in a number of different approaches.”

The study was supported by the Israel Cancer Research Foundation, the Israel Cancer Association and the Israel Science Foundation.


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