Raw data in EEG can reveal Parkinson’s disease

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Specific angles and sharpness of brain waves seen in unfiltered raw data from scalp electroencephalograms have been tied to Parkinson’s disease.

Reporting in the online journal eNeuro, researchers suggest that noninvasive EEG readings may provide easily detectable electrophysiological biomarkers to aid the diagnosis and fine-tune therapeutic treatments for the disease and potentially other motor disorders.

“Using this safe and affordable way to measure and quantify brain activity, we were able to distinguish differences between Parkinson’s patients who were on and off medications and in comparisons with healthy people,” said the study’s principal investigator Nicole Swann of the Department of Human Physiology at the University of Oregon.

The initial diagnosis of Parkinson’s disease currently relies on a neurologist’s assessment of patients performing a series of body-movement tasks.

Such subjective testing, however, can lead to misdiagnosis.

“We don’t know yet whether this approach will be better, but it could provide easily obtained brain measurements that would be helpful and possibly used in tandem with clinical observations and other EEG measurements,” Swann said.

Previous efforts to detect Parkinson’s disease in EEG brain waves have been inconsistent, she said, because the focus has been on measures which model brain signals as sine waves, which are beta waves filtered to round the waves and show the overall power of periodic oscillations.


Schematic summarizing waveform shape calculations. Credit: Jackson et al., eNeuro (2019)

Novel methods like the one used here currently have only been shown to relate to Parkinson’s disease with electrodes surgically implanted in patients’ brains.

In the new analysis of scalp EEG data, previously collected at the University of California San Diego from 15 Parkinson’s patients and 16 healthy control participants, Swann focused on the original unfiltered beta waves to look for specific angles and full shape of the oscillations.

Co-author Scott Cole, a doctoral student at UC San Diego in 2017, had noticed that people with Parkinson’s disease appear to have sharp brain waves, suggesting a new look was warranted.

“The raw signals go up and down like sine waves but with more asymmetry,” Swann said. “The steepness—the slant—turns out to be important in Parkinson’s patients. This was easily detectable in the patients who are off medication.”

When the peak is sharper at the top of the wave than in the trough, or low part of the oscillation, it is indicative of patients who are off their medications, she said.

In a large follow-up study, Swann said she hopes to combine scalp EEG measurements with detailed medical histories and self-reports of how patients are feeling on each day of testing.

Eventually, it is hoped the approach could help detect changes in the disease in individuals over time.

Current treatment involves surgery to permanently implant an electric stimulator or a pharmacological approach in which dosage titration is difficult and often results in frustrating cycling of effectiveness, said study co-author Bradley Voytek, a neuroscientist at UC San Diego, in whose lab Cole, who has since earned his doctorate, had worked.

“If there were real-time measures of how effective treatments are at reducing the negative symptoms of Parkinson’s disease, treatments could be adjusted in real-time,” Voytek said.

“In the case of an invasive brain stimulator, this might mean only applying electric stimulation when it’s needed.

In the case of pharmacology, it would mean adjusting a drug’s dose much like continuous glucose monitoring done by an implant can signal a pump to adjust insulin levels as needed.”

Ideally, Swann said, if the approach proves to provide robust information, EEG testing could be remotely done by Parkinson’s patients wearing a hat fitted with electrodes. Results could be sent to their neurologists and used to quickly and easily adjust treatments.

A challenge, Voytek said, is that real-time measures of brain activity are often noisy and can cloud the ability to capture the correct signals.

“A lot of the tools we have for measuring them take a lot of processing power, so they can’t easily be applied in real-time,” he said.


Cognitive decline is common with the progression of Parkinson’s disease (PD).

Different candidate biomarkers are currently studied for the risk of dementia in PD.

Several studies have shown that quantitative EEG (QEEG) is a promising predictor of PD-related cognitive decline. In this paper we briefly outline the basics of QEEG analysis and analyze the recent publications addressing the predictive value of QEEG in the context of cognitive decline in PD.

The MEDLINE database was searched for relevant publications from January 01, 2005, to March 02, 2015. Twenty-four studies reported QEEG findings in various cognitive states in PD.

Spectral and connectivity markers of QEEG could help to discriminate between PD patients with different level of cognitive decline.

QEEG variables correlate with tools for cognitive assessment over time and are associated with significant hazard ratios to predict PD-related dementia.

QEEG analysis shows high test-retest reliability and avoids learning effects associated with some neuropsychological testing; it is noninvasive and relatively easy to repeat.

Basics of Quantitative Analysis of EEG

QEEG is a mathematical processing of EEG data to extract relevant information for subsequent analysis or comparison with other kinds of data [1516].

In contrast to conventional EEG, where electrical activity of the brain cells is visually analyzed, QEEG provides derivative parameters, which are generated from EEG “raw” data using computational methods. QEEG includes several procedural steps (Figure 1).

The first step consists ofEEG signal acquisition itself, performed with the use of various EEG machines and electrode systems.

Alternatively, MEG may be used. MEG is the recording of the magnetic fields, generated by the ionic currents at the brain cellular level; thus, both EEG and MEG are methodologically similar and relevant in neuroscience [17].

The second step includes preprocessing, eliminating the following artifacts: muscle movements, sleepiness, eye blinks, heartbeat, and other types of EEG “noise.” Preprocessing is performed by selecting “clean” EEG segments for analysis.

The last stage is mathematical processing of the “clean” (artifact-free) EEG signal to extract a parameter, which denotes best the process of interest (e.g., cognitive decline). Various mathematical approaches are used for the processing; they are generally classified in linear and nonlinear techniques.

Linear methods are based on the concept that electric activity of the brain is a stationary process [18]. Nonlinear methods are based on the concept that EEG activity is a dynamic and irregular phenomenon [19].

Each of these methods has its advantages and disadvantages [2021].


More information: Characteristics of Waveform Shape in Parkinson’s Disease Detected with Scalp Electroencephalography, eNeuroDOI: 10.1523/ENEURO.0151-19.2019 , https://www.biorxiv.org/content/10.1101/534396v2

Provided by University of Oregon

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