Eating a cup of blueberries a day reduces risk factors for cardiovascular disease

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Eating a cup of blueberries a day reduces risk factors for cardiovascular disease – according to new research led by the University of East Anglia, in collaboration with colleagues from Harvard and across the UK.

New findings published today in the American Journal of Clinical Nutrition show that eating 150g of blueberries daily reduces the risk of cardiovascular disease by up to 15 percent.

The research team from UEA’s Department of Nutrition and Preventive Medicine, Norwich Medical School, say that blueberries and other berries should be included in dietary strategies to reduce the risk of cardiovascular disease – particularly among at risk groups.

The team set out to see whether eating blueberries had any effect on Metabolic Syndrome – a condition, affecting one-third of westernised adults, which comprises at least three of the following risk factors: high blood pressure, high blood sugar, excess body fat around the waist, low levels of ‘good cholesterol’ and high levels of triglycerides.

Lead researcher Prof Aedin Cassidy, from UEA’s Norwich Medical School, said: “Having Metabolic syndrome significantly increases the risk of heart disease, stroke and diabetes and often statins and other medications are prescribed to help control this risk.

“It’s widely recognized that lifestyle changes, including making simple changes to food choices, can also help.

“Previous studies have indicated that people who regularly eat blueberries have a reduced risk of developing conditions including type 2 diabetes and cardiovascular disease.

This may be because blueberries are high in naturally occurring compounds called anthocyanins, which are the flavonoids responsible for the red and blue color in fruits.

“We wanted to find out whether eating blueberries could help people who have already been identified as being at risk of developing these sort of conditions.”

The team investigated the effects of eating blueberries daily in 138 overweight and obese people, aged between 50 and 75, with Metabolic Syndrome.

The six-month study was the longest trial of its kind.

They looked at the benefits of eating 150 gram portions (one cup) compared to 75 gram portions (half a cup).

The participants consumed the blueberries in freeze-dried form and a placebo group was given a purple-colored alternative made of artificial colors and flavorings.

Co-lead, Dr. Peter Curtis, also from UEA’s Norwich Medical School, said: “We found that eating one cup of blueberries per day resulted in sustained improvements in vascular function and arterial stiffness—making enough of a difference to reduce the risk of cardiovascular disease by between 12 and 15 percent.

“The simple and attainable message is to consume one cup of blueberries daily to improve cardiovascular health.

“Unexpectedly, we found no benefit of a smaller 75 gram (half cup) daily intake of blueberries in this at-risk group. It is possible that higher daily intakes may be needed for heart health benefits in obese, at-risk populations, compared with the general population.”


Nutritional epidemiology provides some evidence regarding the cardio-protective effects of foods high in polyphenols, such as berries, tea, soy, and cocoa products (14).

Blueberries are particularly high in polyphenolic flavonoids in addition to containing significant amounts of micronutrients and fiber (57).

American blueberries include the lowbush or wild blueberry (Vaccinium angustifolium Aiton) and the highbush or cultivated blueberry (Vaccinium corymbosum L.), both of which have superior ranking among fruits and vegetables for their antioxidant capacity, mainly due to their high anthocyanin content (93–235 mg/100 g berries) (67).

In a comprehensive analysis of the antioxidant potential of commonly consumed polyphenol-rich beverages in the United States, blueberry juice was ranked among the top 4 contributors of dietary antioxidants after pomegranate juice, red wine, and concord grape juice (8).

Berries have been commercialized as fresh or frozen whole fruits, freeze-dried berries, puree, juice, or wine (911). Although most processing methods cause a significant decrease in the anthocyanin content (1012), freeze-drying has been reported to cause the least reduction in total polyphenol content of berries (11).

Several mechanistic studies provide evidence of antioxidative (1314), antiinflammatory (1415), antihypertensive (1617), antidiabetic (1819), antiobesity (20), and antihyperlipidemic (2021) effects of blueberries, providing possible rationale for cardio-protective mechanisms.

Based on these mechanistic studies, consuming blueberries might favorably alter individual components of metabolic syndrome, a rapidly escalating public health problem in the US (22).

Metabolic syndrome has been characterized by abdominal adiposity, dyslipidemia (high triglycerides, low HDL cholesterol), hypertension, impaired glucose tolerance, elevated oxidative stress, inflammation, and increased risks for type 2 diabetes and atherosclerotic cardiovascular disease (CVD)7 (2224).

Berry supplementation using chokeberries, cranberries, or a combination of berries has been shown to improve features of metabolic syndrome such as dyslipidemia, hypertension, or impaired fasting glucose in participants with existing cardiovascular risk factors (2527). However, there is a paucity of clinical data on the cardiovascular health benefits of blueberries per se.


More information: Peter J Curtis et al. Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome—results from a 6-month, double-blind, randomized controlled trial, The American Journal of Clinical Nutrition (2018). DOI: 10.1093/ajcn/nqy380

Journal information: American Journal of Clinical Nutrition
Provided by University of East Anglia

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