Type D Personality and Hypothyroidism


The interaction between psychological traits and physical health conditions remains a complex and intriguing area of medical research. Among these, the relationship between Type D personality and hypothyroidism presents a nuanced landscape of intertwined physical and emotional health challenges. This article delves into the prevalence of overt and subclinical hypothyroidism, the persistent symptoms in individuals with regulated thyroid-stimulating hormone (TSH) levels, and the potential influences of Type D personality on these individuals’ health outcomes.

Hypothyroidism: A Global Health Concern

Hypothyroidism is a prevalent endocrine disorder with global statistics indicating a prevalence rate of 0.2% to 5.3% for overt hypothyroidism and up to 10% for subclinical hypothyroidism. Despite the clinical management of serum TSH within the reference range, a significant portion of patients, approximately 10% to 15%, continue to experience persistent symptoms. These symptoms often complicate the clinical picture and challenge the efficacy of conventional treatment paradigms, primarily involving levothyroxine (L-T4) therapy.

Persistent Symptoms and Underlying Hypotheses

The persistence of symptoms in individuals with seemingly well-managed hypothyroidism has led to various hypotheses. The inability of L-T4 therapy to mimic the physiological intricacies of endogenous thyroid hormone distribution and its effect on tissue-level T3 concentrations is a primary concern. Additionally, the role of comorbidities, the inflammatory processes associated with autoimmunity, and the potential suboptimal administration or absorption of L-T4 contribute to the complexity of managing hypothyroidism effectively. Notably, the prevalence of somatic symptom disorder (SSD) and the psychological impact of being labeled with a chronic disease have also been recognized as significant factors that may exacerbate or mimic the symptoms of hypothyroidism.

The Impact of Type D Personality

Type D personality, characterized by a combination of high negative affectivity (NA) and social inhibition (SI), is associated with poor health outcomes and has been extensively studied in patients with cardiovascular diseases. Individuals with this personality type exhibit a tendency towards pessimism, worry, and stress, which can influence their overall health, quality of life, mental health status, treatment outcomes, and medication adherence. The Type D Scale-14 (DS14) questionnaire is a validated tool used to identify individuals with Type D personality, revealing a global prevalence rate of approximately 21.0% to 38.5%.

Type D Personality in Hypothyroidism

The exploration of Type D personality within the hypothyroidism patient population is limited but crucial. Studies in thyroid disease have primarily focused on thyroid cancer survivors, where Type D personality was not a significant predictor of quality of life or medication adherence. However, the broader implications of Type D personality on individuals with hypothyroidism, particularly those with persistent symptoms despite optimized TSH levels, remain underexplored.

Study Objectives and Questions

This study aims to bridge the gap in understanding the prevalence of Type D personality among individuals with hypothyroidism and its potential impact on patient-reported outcomes. Specifically, the study addresses two primary questions:

  • What is the prevalence of Type D personality among people with hypothyroidism?
  • How does Type D personality relate to the characteristics of the respondents and the patient-reported outcomes associated with hypothyroidism?

Comprehensive Approach to Understanding Type D Personality and Hypothyroidism

To answer these questions, a multifaceted research approach is adopted, combining quantitative and qualitative methodologies to assess the prevalence of Type D personality and its correlations with various aspects of hypothyroidism. This comprehensive analysis will consider the intricate dynamics between physical symptoms, psychological traits, and their collective impact on the quality of life and management of hypothyroidism.


The intersection of Type D personality and hypothyroidism represents a significant area of clinical interest with potential implications for patient management and therapeutic strategies. By unraveling the complex relationship between these two entities, healthcare professionals can gain insights into the multifactorial nature of persistent symptoms in hypothyroidism and the broader psychological aspects influencing patient health outcomes. This study not only aims to shed light on the prevalence and impact of Type D personality in the context of hypothyroidism but also seeks to inform more nuanced, patient-centered approaches to managing this prevalent endocrine disorder.

reference link : https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae140/7640726


Please enter your comment!
Please enter your name here

Questo sito usa Akismet per ridurre lo spam. Scopri come i tuoi dati vengono elaborati.