ISRAEL – West Nile Fever Outbreak: A Comprehensive Analysis


Recent Outbreak and Current Status

As of today, the Health Ministry has confirmed that 104 patients have been diagnosed with West Nile Fever in the recent outbreak, with 68 of these patients requiring hospitalization. Tragically, eight people have succumbed to the disease. In response to this alarming surge in cases, a special emergency committee was convened in the Knesset yesterday, highlighting the severity of the situation and the urgent need for effective measures to curb the spread of the virus.

Understanding West Nile Virus

West Nile virus (WNV) is a mosquito-borne pathogen that can cause serious illness in humans, birds, and other animals. It belongs to the Flavivirus family, which includes other significant viruses such as dengue, Zika, and Japanese encephalitis. WNV primarily circulates in birds, with mosquitoes acting as vectors that transmit the virus to humans and other animals.

Transmission and Epidemiology

WNV is most commonly transmitted through the bite of infected mosquitoes, particularly those of the Culex species. In Israel, the primary vectors are Culex pipiens and Culex perexiguus. Other mosquito species, including Aedes and Anopheles, can also carry the virus, although their role in transmission is considered secondary.

The virus was first identified in the West Nile district of Uganda in 1937. Since then, it has spread to various parts of the world, including Africa, Europe, Asia, and the Americas. In Israel, WNV has been present since the 1940s, with notable outbreaks occurring in the 1950s, 1970s, and more recently in 2000, 2005, 2007, and 2010. The virus was introduced to the United States in 1999, leading to significant outbreaks across North and South America.

Factors Influencing Spread

The spread of WNV is influenced by a complex interplay of natural and human-related factors. These include:

  • Mosquito and Bird Species: Different mosquito species vary in their efficiency as vectors. Similarly, some bird species are more susceptible to infection and play a crucial role in amplifying the virus.
  • Climate and Environmental Conditions: Temperature, rainfall, and humidity significantly affect mosquito breeding and survival rates. Global warming and changing weather patterns can alter the distribution and activity of mosquitoes.
  • Human Activities: Urbanization, global trade, and travel can facilitate the spread of mosquitoes and the viruses they carry. Poor waste management and inadequate drainage systems can create breeding grounds for mosquitoes.
  • Immune System of Hosts: The susceptibility of humans and animals to WNV infection can vary based on their immune status and overall health.

Seasonal Activity

In Israel, WNV activity typically peaks between August and November, with the highest transmission rates usually observed in the third week of September. However, variations can occur, as seen in the current outbreak, where peak transmission appears to have shifted earlier by a month.

Image : West Nile Virus Disease – Israel – Ministry of Health – resource :

Symptoms and Clinical Presentation

The incubation period for WNV ranges from 2 to 14 days, with an average of 6 days. The majority of infected individuals (approximately 80%) are asymptomatic. When symptoms do occur, they are often mild and flu-like, including:

  • Fever
  • Headaches
  • Joint and muscle pains
  • Nausea and vomiting
  • Rash
  • Eye pain

Most symptomatic cases resolve within 3 to 6 days. However, severe illness can develop in about 1 in 150 infected individuals, leading to neurological complications such as meningitis, encephalitis, and acute flaccid paralysis. Severe cases can result in long-term disability or death, particularly among older adults and individuals with compromised immune systems.

Recent Outbreak Data and Response

The recent outbreak has prompted swift action from health authorities. The Health Ministry has been closely monitoring the situation, implementing measures to prevent further spread and providing guidance on protective actions. Key steps taken include:

  1. Public Awareness Campaigns: Educating the public about the symptoms of WNV, preventive measures, and the importance of seeking medical attention if symptoms develop.
  2. Vector Control Efforts: Intensifying mosquito control activities, including larviciding and adulticiding, to reduce mosquito populations.
  3. Environmental Management: Encouraging the public to eliminate standing water sources around their homes, which serve as breeding sites for mosquitoes.
  4. Medical Preparedness: Ensuring that healthcare facilities are equipped to diagnose and treat WNV cases, and that healthcare professionals are informed about the latest treatment protocols.

Protective Measures and Prevention

Effective prevention of WNV involves reducing exposure to mosquito bites and minimizing mosquito populations. The following protective measures are recommended:

Personal Protection:

  • Clothing: Wearing long-sleeved shirts and long pants when outdoors during mosquito-active hours (sunset to sunrise).
  • Repellents: Using insect repellents containing DEET, picaridin, IR3535, or oil of lemon eucalyptus on exposed skin and clothing.
  • Screens and Nets: Installing screens on windows and doors to prevent mosquitoes from entering homes, and using mosquito nets while sleeping, particularly in areas with high mosquito activity.
  • Fans: Operating fans indoors and outdoors to create air movement that can disrupt mosquito flight and reduce bites.

Environmental Management:

  • Eliminate Standing Water: Regularly emptying and cleaning containers that collect water, such as flowerpots, birdbaths, and gutters.
  • Maintain Decorative Ponds: Ensuring that ponds are stocked with fish that eat mosquito larvae.
  • Proper Waste Disposal: Removing discarded items that can collect water, such as tires and plastic containers.
  • Report Hazards: Informing municipal authorities about standing water or mosquito breeding sites in public areas.

Chemical and Physical Control:

  • Larvicides: Applying larvicides to standing water sources to kill mosquito larvae.
  • Adulticides: Using adulticides to reduce adult mosquito populations in high-risk areas.
  • Repellent-Soaked Fabrics: Utilizing mosquito nets, clothing, and camping gear treated with insect repellents such as permethrin.

Emerging Trends and Research

Recent research has focused on understanding the genetic diversity of WNV and its impact on transmission dynamics. Scientists in Israel have identified new viral genotypes each year, closely resembling strains from Europe, Russia, and Africa. These findings underscore the importance of continuous surveillance and research to track the evolution of the virus and its potential impact on public health.

Additionally, advancements in vector control technologies, such as genetically modified mosquitoes and novel insecticides, hold promise for more effective and sustainable mosquito management. Efforts are also underway to develop vaccines and antiviral treatments for WNV, which could provide additional tools for preventing and managing outbreaks.

Global Context and Comparisons

The current outbreak in Israel is part of a broader pattern of WNV activity observed in various regions worldwide. In recent years, significant outbreaks have been reported in Greece, Turkey, Romania, and Russia. In the United States, WNV remains a significant public health concern, with cases reported in nearly every state since the virus was introduced in 1999.

Lessons from Past Outbreaks

Past outbreaks of WNV have provided valuable lessons in outbreak management and prevention. Key takeaways include:

  • Early Detection and Response: Rapid identification and response to outbreaks can help contain the spread of the virus and reduce the impact on public health.
  • Integrated Vector Management: Combining multiple vector control strategies, including environmental management, chemical control, and biological control, can be more effective than relying on a single method.
  • Public Engagement: Engaging communities in prevention efforts, through education and involvement in mosquito control activities, is crucial for reducing mosquito populations and preventing disease transmission.
  • Research and Innovation: Continuous research and innovation are essential for developing new tools and strategies to combat WNV and other vector-borne diseases.


The recent outbreak of West Nile Fever in Israel, with 104 diagnosed cases and eight fatalities, underscores the ongoing threat posed by this mosquito-borne virus. Effective prevention and control measures, informed by scientific research and past experiences, are critical for mitigating the impact of the outbreak and protecting public health. By implementing a comprehensive approach that includes personal protection, environmental management, and vector control, health authorities can reduce the risk of WNV transmission and safeguard the well-being of the population.


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