Slimming Drug Compound May Be An Antidote to Synthetic Cannabis Spice Intoxication

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Early research from Queen Mary University of London has potentially found an antidote that can rapidly stop the intoxicating effects of cannabis and synthetic cannabinoids.

Synthetic cannabinoids, such as ‘Spice’ and ‘Black Mamba’, are becoming an increasing problem, especially with youths game to experiment and within the homeless and prison populations, due to their cheapness and odourless properties.

Their super strength compared to cannabis is leading to an increasing number of severe adverse reactions and an increasing number of deaths.

The study, published in the British Journal of Pharmacology, looked at mice that were experiencing the effects of synthetic cannabinoid intoxication, to see the effects of treating them with a molecule known as AM251.

AM251 blocked the action of the synthetic cannabinoid on one of the brain receptors and led to a loss of the cannabinoid-related behavioural effects within a few minutes. This included a significant loss of sedation within 20 minutes, and a loss of the associated hypothermia within 40 minutes.

Image shows a packet of Spice.

AM251 blocked the action of the synthetic cannabinoid on one of the brain receptors and led to a loss of the cannabinoid-related behavioural effects within a few minutes. NeuroscienceNews.com image is credited to Lance Cpl. Damany S. Coleman.

The researchers say that the most rapid way to develop an antidote would be to re-develop one of the slimming drugs, known as rimonabant, which also blocks the cannabinoid system on which marijuana acts.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source: Joel Winston – Queen Mary University of London
Image Source:  Lance Cpl. Damany S. Coleman.
Original Research: Abstract for “Antidote to cannabinoid intoxication: the CB1 receptor inverse agonist, AM251, reverses hypothermic effects of the CB1 receptor agonist, CB-13, in mice” by Gareth Pryce, and David Baker in British Journal of Pharmacology. Published online September 20 2017 doi:10.1111/bph.13973

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