A team of researchers affiliated with several institutions in the U.S. has found that office workers sleep more hours each night when exposed to more sunlight during the day.
In their paper published in the International Journal of Environmental Research and Public Health, the group describes their experiments in real office buildings and what they learned from them.
Prior research has shown that when office workers are exposed to minimal natural light during their shifts, they tend to sleep less at night than people who are exposed to more sunlight during the day – they also tend to perform less well on cognitive tests.
Prior research has also shown that children exposed to more sunlight during the day tend to sleep longer than those who see little daylight. In this new effort, the researchers sought to learn more about the sunlight/sleep connection by carrying out an experiment in two adjacent offices in an office building in Durham, North Carolina.
The experiments involved testing the differences in sleep patterns for people working in nearly identical office environments situated right next to each other – the only real difference was the lighting.
One office had the traditional blinds that obscure much of the sunlight coming through the large glass windows. In the other office, the windows were treated with electrochromic glazing technology that allows more sunlight to pass through while still minimizing glare.
For the experiment, typical office workers were asked to work in both offices for one week. At the end of the week, the workers were asked to trade offices where they worked for another week. Also, each of the workers was fitted with a wrist actigraph that measured and recorded how long the wearer was asleep each night.
The researchers found that both groups of workers slept longer when they worked in the office with more natural lighting – on average 37 minutes longer.
The researchers found that the positive effects of sunlight grew as the week wore on—scores on cognitive tests improved each day. By the end of the week, the workers scored 42 percent higher. The researchers suggest their findings show that lighting should feature more prominently in the workplace, and that doing so would benefit both workers and those who employ them.
Fundamentals of light
To understand the effects of light on the human physiology, it is important to understand light. Briefly, light is radiation in a specific range of the electromagnetic spectrum. It is best and most completely described by its spectral distribution, which quantifies the amount of energy (or the number of photons) as a function of wavelength (with visible light in the wavelength range between 380 and 780 nm).
During the day, light intensities outside can reach illuminances up to 100,000 lx in direct sunlight and 25,000 lx in full daylight. Light intensities in closed rooms are considerably lower and standard office lighting is only ~500 lx, often lower [37, 81].
The spectrum of daylight, which is light from the sun filtered by the atmosphere is relatively broadband in its distribution (Fig. 2a). The availability of daylight depends on geographical location and season. In the timeframe of human evolution, it is a rather recent development that light can be available during all times of day through artificial light.
Artificial light allows for illuminating indoor and outdoor spaces. It comes in many forms, e.g. incandescent, fluorescent, or light-emitting diode (LED) lighting.
While light generated by these technologies may all appear “white”, the underlying spectra are rather different (Fig. 2b). The reason why many different types of spectra might have the same appearance lies in the retina.
Critically, different spectra, even if they create the same visual impression, may vary in their chronobiological effects on the circadian clock.
It is important to keep in mind that there are multiple ways how light is quantified and reported in the literature in particular when focussing on its repercussions on human physiology.
For example, while the absolute spectral distribution of a light is the most complete description, many investigators report the illuminance (in lux [lx]), or the correlated colour temperature, which is the temperature of a hypothetical black-body radiator with the same colour as the light source in question.
Unfortunately, until recently, there have been no standard quantities that experimenters were asked to report, and therefore, summarising the chronobiological and somnological literature on the effects of light remains a challenge. Recently, the Commission International de l’Eclairage (CIE), the international standard body for quantities related to light, issued a new standard containing a reference framework for quantifying the effects of light on non-visual functions .
In practice, experimenters employing light as an intervention should report, at a minimum, the spectral power distribution of the light, as seen from the participant’s point of view. Detailed minimum guidelines are given in .
Photoreceptors in the retina
In humans, the known effects of light on circadian rhythms and sleep are all, without exception, mediated by the retina. The retina is a fine layer of nerve tissue at the back of our eyes, containing specialised photoreceptors (Fig. 3a). The so-called cones exist in the highest density in the centre of the retina—the fovea.
There are three types of cones, differing in their preference for light at specific wavelengths (Fig. 3b): The long-wavelength-sensitive cones (L cones), the medium-wavelength-sensitive cone (M cones) and the short-wavelength-sensitive cones (S cones). Cones allow us to see colour, spatial detail and motion at light levels typical for daytime.
Rods, by contrast, are suppressed at daytime light levels and only signal at light levels typical for twilight and darker. Rods are absent in the fovea, cannot distinguish between different colours and only allow for rudimentary vision.
Cones and rods are not the only photoreceptors in the retina. A small fraction of secondary neurons in the retina—the retinal ganglion cells (RGCs), which integrate information and send it to the brain via the optic nerve—express the photopigment melanopsin .
Melanopsin is a short-wavelength-sensitive pigment with a peak spectral sensitivity near around 480 nm , rendering some RGCs intrinsically photosensitive . These intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to mediate most effects of light on the circadian clock.
However, ipRGCs are not independent of rod and cone input. Rather, they also receive information from these receptors, suggesting that ipRGCs indeed act as “integrators of information” regarding the light environment across a wide range of wavelengths and light levels.
Surprisingly, the input from the S cones into the ipRGCs has a negative sign . In humans, this has the paradoxical consequence that increases in S cone activation lead to a dilation of the pupil [80, 100], which is also controlled by the ipRGCs.
It has long been thought that cones and rods mediate what is typically considered “vision” (seeing colour, motion, spatial detail), and that melanopsin mediates the “other”, non-visual effects of light, i.e. melatonin suppression, circadian phase shifting, and alertness. However, at second sight, this dichotomy breaks down.
There is now converging evidence that melanopsin signals reach the primary visual cortex (V1) , where they may contribute to and modulate our visual perception [20, 25, 109].
It is important to keep in mind that the retinal photoreceptors experience an altered version of the light relative to the cornea, the front surface of the eye. This is because the eye itself contains filters.
In the centre of the retina, this includes the macular pigment, which is present in the fovea but drops off in the peripheral retina. More importantly for ipRGCs, the crystalline lens and ocular media filter out short-wavelength light.
This natural “blue-blocking” filter increases density with increasing age, with less and less short-wavelength light reaching the retina.
While the field of vision science has a long history (>150 years) in examining how different types of light stimuli are encoded, processed and perceived, we still remain largely in the dark about many aspects of the effects of light on the circadian clock.
The discovery that the production of melatonin is suppressed in humans in response to light dates back to only 1980 .
Teasing apart how the different elements in the retina contribute to the effects of light on circadian rhythms, sleep and mood remains an important challenge.
Effects of light on the circadian clock
Two effects of light have been interrogated extensively in human circadian and sleep research:
(1) the acute suppression of melatonin in response to light exposure and
(2) the ability of light exposure to shift circadian phase.
However, these two effects are not arising from a unitary pathway resulting in a direct relationship between melatonin suppression and phase shifts. There is now accruing evidence that they may be indeed separable . As a consequence, one should not be used as a proxy for the other .
The system mediating melatonin suppression has a spectral sensitivity that is broadly consistent with the spectral sensitivity of melanopsin [17, 60, 88]. Similarly, the spectral sensitivity of circadian phase shifting shows its maximal effect near the peak spectral sensitivity of melanopsin .
However, this does not imply that cones and rods may not participate in these non-visual effects of light. Indeed, there is evidence that cones do contribute, though at a different time scale than the ipRGCs .
The effects of light on the phase of the circadian clock depend on the timing of light exposure. This is formally summarised in the phase response curve (PRC), which describes the amount of phase shift (in minutes and hours) achieved by exposure of light at a given circadian phase.
Roughly speaking, the effect of morning light is that it advances the clock, while evening and night light delays the clock. The human circadian system integrates across multiple light exposures as short as five minutes , even intermittent bright light exposure can shift the circadian phase [43, 66].
It has been shown that under certain circumstances, a train of very brief flashes light flashes on the millisecond scale can cause circadian phase shifts which are larger than those caused by continuous light [59, 108].
Both melatonin suppression and circadian phase shifts are modulated by the “photic history”, i.e. the amount of light seen during the day [27, 44, 77]. The long-term adaptive influences of the “spectral diet” in the real world remain an important area of investigation .
Effects of light on sleep
The human sleep–wake cycle, that is periods of sleep during the night and wakefulness during the day, is one of the most prominent examples of a circadian behavioural pattern.
It results from the interaction between two factors: the circadian drive for wakefulness and the homeostatic sleep pressure. The interaction between this circadian “process C” and the homeostatic “process S” has been conceptualised in the widely known “two-process model of sleep” [13, 15], which accounts for the timing and intensity of sleep in many experimental settings.
Indeed, in well-controlled studies the circadian pacemaker in the SCN and the sleep homeostat have been shown to interact in a fashion designed to allow for consolidated periods of wakefulness and sleep during day and night, respectively (e.g. ).
Specifically, the activity of the circadian pacemaker is aligned to counteract the increasing sleep pressure resulting from sustained wakefulness during daytime. Likewise, the nocturnal increase in circadian sleep tendency counteracts the decrease in sleep propensity resulting from accumulated sleep thereby supporting a consolidated phase of nocturnal sleep.
As outlined above, light is the key zeitgeber in the circadian system and interacts with the master clock in the SCN via non-image-forming pathways connecting retina and SCN.
Unsurprisingly, light therefore also affects sleep. Natural daylight at high intensities as experienced outside buildings has previously been shown to
(1) advance the timing of sleep to earlier hours,
(2) affect the duration of sleep, and
(3) improve sleep quality.
More precisely, the phase-advancing effects of daylight have for example been reported by Roenneberg and colleagues  who, using questionnaire data, found that each additional hour spent outdoors advanced sleep by ~30 min.
Despite light being the strongest zeitgeber, this phase-advance could also result from physical exercise during daytime [102, 105], which is often confounded with time spent outdoors.
The relative contributions of light and physical activity remain to be determined. Moreover, light exposure during the day has also been shown to affect sleep duration. Here, shorter daylight exposure and longer nights are associated with a longer biological night as indexed by the duration of melatonin secretion, and thus longer sleep duration [85, 94, 95], which may also reflect a seasonality effect .
Likewise, exposure to daylight has been shown to increase sleep duration, possibly by advancing sleep timing . Beyond this, sleep quality is also related to light exposure during the day.
Several studies report that daytime exposure to white light enriched in short-wavelength content was associated with increased evening fatigue , and sleep quality [16, 39, 91], decreased sleep-onset latency , and increased slow-wave sleep accumulation , which is related to the dissipation of the homeostatic sleep pressure [1, 14, 34].
However, also the timing of light exposure seems to matter for sleep. In this context, Wams and colleagues  report that participants with later exposure to light >10 lx had more nocturnal awakenings and less slow-wave sleep. In sum, research seems to agree that daylight (at high intensities) is beneficial for sleep.
Exposure to artificial lighting, smartphones and visual display units
In addition to natural daylight, humans are nowadays also exposed to a considerable amount of artificial light. This is particularly the case in the evening hours, i.e. when the circadian system is most sensitive to light-induced phase delays.
Thereby, artificial light can delay the timing of the circadian clock and thus sleep . Indeed, light from LED screens has repeatedly been suggested to interfere with sleep and the physiological processes involved (e.g., melatonin secretion ).
Chang and colleagues  for example found that reading a book from an e‑reader for four hours before sleep increased sleep onset latency, reduced evening sleepiness, melatonin secretion as well as next-morning alertness, and delayed the timing of the biological clock, which is also in line with other findings [72, 107].
It should be noted though that exposure to the “circadian-active” light source was very long in these studies (4–6.5 h) and it is unclear whether the same results can be expected for shorter exposures.
Evaluating sleep objectively with electroencephalography (EEG), Münch and colleagues  found that exposure to short-wavelength light for two hours starting 3 h before habitual bedtime first lead to decreased slow wave activity (SWA) and thus shallower sleep.
From this, the authors concluded that the alerting effects of short-wavelength light persist into sleep, which is in line with findings by Chellappa and colleagues , who reported a decrease in homeostatic sleep pressure following short-wavelength light exposure in the evening. However, short-wavelength light exposure in the evening was also associated with increased SWA later during the night, suggesting a possible compensatory mechanism .
Also, the effects of evening light exposure do not seem to be independent from exposure during the preceding day. More specifically, Rångtell and colleagues  examined the effects of reading a novel on a tablet computer (~102 ± 41 lx, 7718 K) vs. in a physical book (~67 ± 50 lx, 2674 K) for two hours following prolonged (6.5 h) exposure to bright light (~569 lx, 3149 K) between 2:30 pm and 9 pm. Contrasting other findings, the light from the tablet did not suppress melatonin or alter subjective and objective sleep parameters. Note though that also exposure was shorter than in studies that reported significant effects [26, 72, 107].
Several studies have reported that smartphone ownership and use before bedtime may be associated with more self-reported sleeping problems , decreased sleep efficiency, longer sleep onset latency and poor sleep quality , and delays sleep thereby also shortening sleep duration [29, 50, 74].
Modern smartphones contain a “night shift” feature changing the colour balance in the evening hours (Infobox 1 for details). How much of the reported detrimental effect of smartphone use on sleep is due to light per se, or to some other feature (e.g. psychological engagement), is currently not known.
Infobox 1 Smartphones and sleep
Smartphone use may delay sleep onset. One factor is the light emitted by their screens, but another may also be its entertaining character or related psychological effects, or both. Using the “night shift” mode of modern smartphones, the colour balance of the screen can be shifted to “warmer” and orangeish colours depleted in short-wavelength light.
On a recent iPhone 7, this amounts to a reduction of melanopsin activation by 67% at full display brightness. This might seem like a large reduction at first, though by simply dimming the smartphone to its minimum level, the melanopsin activation can be reduced to less than 1% of the activation at maximum display brightness.
Whether or not the “night shift mode” has an appreciable effect on the circadian system and how it interacts with other properties of smartphone use is currently not known. Recent research using so-called metameric displays, which do not differ in their appearance but only differ in the amount that they stimulate melanopsin, show that the non-visual properties of light can be modulated independently of visual appearance [3, 78].
Effects of light on mood
Mood variations have been shown to be influenced by a complex and non-additive interaction between circadian phase and the duration of prior wakefulness. Specifically, relatively moderate changes in the timing of the sleep–wake cycle can significantly modulate mood .
Light can affect mood in several ways: by directly modulating the availability of neurotransmitters such as serotonin, which is involved in mood regulation, and by entraining and stabilising circadian rhythms, thereby addressing circadian desynchronisation and sleep disorders, which are rather common in people suffering from mental disorders. Therefore, in the last decades, light as an intervention—light therapy—has found an increasingly widespread use for treating mood and other psychiatric disorders [73, 97].
The precise mechanisms by which light exerts a positive influence on mood are currently not known though. In addition to the circadian effects of light mediated via the SCN, a pathway from the retina to the habenula has recently been found to be involved in mediating effects of light on mood in animal models [38, 110].
This pathway, connecting some ipRGCs with the habenula and bypassing the SCN altogether, has been suggested to specifically mediate light-induced alterations in mood . Although it is unclear to what extent these findings can be applied to humans, imaging studies at least suggest that the human habenula is also sensitive to modulations of ambient light . More research is needed to identify the mechanisms underlying light therapy.
In the following, we will provide an overview of the major clinical applications of light therapy and a brief guide to its use in daily clinical practice.
Light therapy as an intervention in psychiatric conditions
Bright light therapy (BLT) for mood disorders was first introduced for the treatment of Seasonal Affective Disorder (SAD) in 1984 . SAD is a subtype of depression characterised by strong seasonal variations in mood states.
BLT is nowadays established as first-line treatment for SAD [61, 75] leading to an amelioration of symptoms after a few days of treatment. Light therapy is also effective as second-line treatment for non-seasonal depression, although it usually takes longer (2–5 weeks) than in SAD to achieve a therapeutic effect [2, 75, 87].
BLT, especially in combination with selective serotonin reuptake inhibitors (SSRIs), can accelerate the clinical improvement and lead to significantly fewer residual symptoms [7, 53]. In patients with chronic depression, BLT has been shown to lead to remarkable remission rates compared to placebo  and represents a valid therapeutic option also in gender-related mood disorders, such as premenstrual dysphoric disorder and perinatal depression [47, 96].
BLT can be delivered by special, commercially available therapy lamps, which operate at illuminance levels between 7000 and 10,000 lx, but natural daylight during a regular one-hour morning walk has been shown to be similarly effective .
In populations who suffer from depressive mood resulting from of a lack of exposure to natural daylight due to, for example, working duties in shift workers, patients with altered sleep–wake rhythms (e.g. delayed sleep–wake phase disorder), or social withdrawal (patients with psychiatric disorders, elderly people), BLT provides an effective treatment and valid alternative to pharmacological approaches .
Not only “active” chronotherapeutic approaches, but also an adequate architectural design of the light environment may have relevant clinical implications for psychiatric patients. The availability of light in hospital rooms has been shown to decrease the length of stay of depressed patients in a clinic . Moreover, retrospective analyses revealed a three-day shorter hospitalisation in bipolar depressed inpatients exposed to natural light in sunny hospital rooms compared to those in darker rooms .
Light therapy as an intervention in other medical conditions
In recent years, light therapy has been increasingly implemented as an adjunctive therapy for several other medical conditions. In patients with anorexia or bulimia nervosa, light not only improves mood but also helps to better control specific disease-related symptoms (for a review see [5, 49]).
Well-controlled longitudinal studies have demonstrated that light not only has antidepressant effects in age-related depression, but can also slow down the progressive cognitive decline in dementia [52, 65].
More generally, due to its rhythm-synchronising properties and its enhancing effects on sleep quality and wakefulness, BLT is becoming an important tool in geriatric care, to treat sleep–wake disturbances and reduce general listlessness .
The stabilising effects of light also make BLT a useful additional treatment in adult attention deficit hyperactivity disorder (ADHD) , borderline personality disorder , and other conditions characterised by sleep–wake disruption, such as schizophrenia  or neurodegenerative diseases .
New applications are also emerging in internal medicine, e.g. in intensive care units, where day and night differences in lighting are often severely attenuated, which may result in patients developing a fragmented sleep–wake cycle with a negative impact on their recovery .
Studies have also demonstrated beneficial effects of BLT in patients with sleep–wake abnormalities after renal transplantation  or in cirrhotic patients , as well as in severely brain-injured patients in post-comatose states [9, 10], and Parkinson’s disease .
Finally, one of the most common applications of light, often in combination with exogenous melatonin, is found in sleep medicine [70, 71] for the treatment of specific circadian rhythm sleep–wake disorders (CRSWD), including advanced and delayed sleep–wake phase disorder, jet lag, shift work, sighted non-24 and irregular sleep–wake phase disorder (for diagnostic criteria see ).
Light therapy in practice
Timing, frequency and duration of light therapy sessions
The antidepressant effect of light is most pronounced when it is administered in the early morning hours [86, 97].
For CRSWD, the timing of therapeutic light exposure depends on the type of circadian disturbance and the direction of phase shift (advance or delay) to be pursued in order to achieve circadian resynchronisation.
Therefore, a reliable marker of circadian phase should be first assessed to identify the phase position and then determine the timing of light treatment. The gold standard for measuring circadian phase is obtained by quantifying the so-called dim light melatonin onset (DLMO), i.e. the time at which melatonin levels rise above baseline, indicating that melatonin secretion has started.
However, implementing DLMO assessment in the clinical practice remains difficult due to the limited availability of equipped centres that perform melatonin analyses and the costs of this diagnostic procedure, which are currently not reimbursed by health insurances in most European countries.
BLT is particularly effective when exposure to light occurs regularly, i.e. on a daily basis, for at least 30–60 min. Therefore, it is commonly performed in a domestic setting, which facilitates the required compliance, especially regarding timing, frequency, and duration of the treatment sessions.
Disease relapses due to lacking therapeutic adherence depend on the underlying pathological condition: while SAD may rapidly reappear after a short therapy break, isolated days without light therapy are unlikely to have any negative consequences on circadian rhythm stabilisation in CRSWD, if regular sleep-wake schedules are maintained.
Light therapy devices
Most light therapy devices on the market are suitable for clinical use. They reach a corneal illuminance of 7000–10,000 lx at a viewing distance of 20–35 cm and are equipped with a protective screen with almost complete UV filtering.
Ideally designed devices illuminate the patient diagonally from above with an irradiation angle of ~ 15°. A bevelled light surface prevents annoying glare and allows simultaneous reading, thus being better tolerated. To obtain a therapeutic effect, it is not necessary to look directly into the light source, but the eyes must be open. Available light therapy glasses, which even allow mobility during the sessions, also partially meet the required criteria of sufficient light illuminance. However, most of them have not yet been evaluated in large, randomised clinical trials. Another alternative to receive light in the early morning hours is through dawn simulators. These devices start providing a relatively weak light signal about 90 min before wake-up time, which, covering the patients’ final sleep cycle, then gradually increases in intensity from about 0.001 lx to about 300 lx. However, also for these devices, the design plays an important role, as a diffuse, wide lighting area is necessary to reach the sleeper in the different lying positions. For the same reason, other types of available miniature lighting devices are not recommended because of their small luminous field .
Adverse reactions to light therapy include eye irritation, blurry vision, grumpiness, headache or nausea after light exposure. However, these effects are usually rare and lessen after a few days of treatment or under reduced dosage .
Isolated cases of increased excitability following light therapy have been reported in patients with bipolar disorder . Occurring sleep problems such as problems related to initiating sleep when light is administered in the evening, or early morning awakenings when light is administered in the morning, are mostly related to an unappropriated time of light exposure and can be quickly resolved by modifying the timing of light therapy sessions.
Some relative contraindications should be taken into account when considering light therapy in patients with ophthalmological diseases or taking photosensitising drugs. These are summarised in Table 1; [22, 40].
Table 1 – Relative contraindications to light therapy. (Modified from )
|Ophthalmological examination recommended in the following conditions||– Pre-existing diseases of the retina or the eye, e.g. retinal detachment, retinitis pigmentosa, glaucoma– Systematic diseases affecting the retina, e.g. diabetes mellitus– Previous cataract surgery or lens removal– Elderly people (increased risk of age-related macular degeneration; AMD)|
|Caution needed by patients taking following photosensitizing drugs||– Neuroleptics (phenothiazines)– Antidepressants (imipramine)– Mood stabilizers (lithium)– Diuretics (hydrochlorothiazide)– 8‑methoxypsoralen– Cardiac medications (propranolol, amiodarone)– Chloroquine– Antibiotics (tetracycline)– “Natural medicines” (melatonin, St. John’s Wort)|
More information: Mohamed Boubekri et al. The Impact of Optimized Daylight and Views on the Sleep Duration and Cognitive Performance of Office Workers, International Journal of Environmental Research and Public Health (2020). DOI: 10.3390/ijerph17093219
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