“There was some evidence of a graded increase with heavier usage, meaning that the more you drink, the greater the increase in arterial stiffness,” said study author Mr. Hugo Walford, a medical student at University College London, UK.
As people get older, their arteries naturally become stiffer and less elastic. Stiffer arteries are associated with higher risks of heart disease and stroke. Certain behaviours can accelerate arterial stiffening. For example, previous research has shown that smoking tobacco and drinking alcohol are linked with stiffer arteries in teenagers.
As young adulthood is a critical period for initiation and heavy usage of smoking and alcohol, this study focused on changes in arterial stiffness between the ages of 17 and 24 and the relationship with these habits.
The study included 1,655 participants of the Avon Longitudinal Study of Parents And Children (ALSPAC) aged 17 to 24 years. Alcohol and smoking were measured at ages 17 and 24 and results at the two time points were combined. Alcohol use was classified as never, medium (4 drinks or less on a typical day of drinking), and high (more than 5 drinks on a typical drinking day).
Smoking was categorised as never, past, medium (less than 10 cigarettes a day), and high (10 or more cigarettes daily).
Arterial stiffness was assessed at ages 17 and 24 using a non-invasive technique called carotid-femoral pulse wave velocity, which is a robust and independent predictor of future cardiovascular disease, especially in young people.
The researchers examined associations between smoking and drinking habits and changes in arterial stiffness between ages 17 and 24. The analyses were adjusted for age, sex, and socioeconomic status, plus the following measures at age 24: body mass index, blood pressure, low-density lipoprotein (LDL) cholesterol, blood glucose, and C-reactive protein (a measure of inflammation).
Arterial stiffness increased by an average of 10.3% from age 17 to 24, with a slightly greater increase observed in women than in men. Arterial stiffness increased with each point rise in the average alcohol score.
No graded increase in arterial stiffness was seen with the average smoking score. While high intensity smokers had a numerically greater increase in arterial stiffness than never smokers, this only reached statistical significance in women. Changes in arterial stiffness between ages 17 and 24 did not differ between ex-smokers and never smokers.
Mr. Walford said: “The results suggest that arterial damage occurs in young drinkers and young women who smoke heavily. Never smokers and ex-smokers had similar alterations in arterial stiffness, indicating that quitting can restore vascular health at this young age.”
He concluded: “Binge drinking is often a normal experience for students, and a falling smoking prevalence in the UK is challenged by a sharp rise in e-cigarette use. Young people may believe that drinking and smoking do not cause long-term damage. However, these results indicate that these behaviours could put young people on a life-course trajectory starting with early arterial stiffening, which may eventually lead to heart disease and stroke.”
Cigarette smoking and consumption of alcohol are associated with increased cardiovascular (CV) risk in adult life.1,2 Smokers are twice as likely to suffer a myocardial infarction compared with people who have never smoked. For alcohol, a J-shaped association has been reported, with CV benefit for those consuming small or moderate amount of alcohol daily. T
his has however been questioned in recent studies,3 which showed that higher intake or binge drinking are associated with increased CV morbidity and mortality4.
Most adult users of alcohol or tobacco first start in their early teens.5,6 In the United States, each day approximately 6000 adolescents, aged 12–18 years, smoke a cigarette for the first time, and 3000 adolescents become daily smokers.7 A large body of research suggests that adolescents who participate in one health-risk behaviour are more likely to engage in additional risk behaviours.7
According to the Center of Disease Classification (CDC), 75% of high school students report drinking alcoholic beverages at least once.7 The early impact of unhealthy behaviours on contemporary arterial disease is not well documented.
The Avon Longitudinal Study of Parents and Children was established in 1991 to provide environmental information on participants from childhood to adolescence and young adulthood and to study the impact on their health (http://www.alspac.bris.ac.uk).8
The cohort has been followed with questionnaires through childhood and at regular annual clinics since age of 7 years. Detailed information about alcohol and smoking is available for participants through adolescence from questionnaires, and vascular phenotyping was performed at age 17 years.
This provided a unique opportunity to assess the impact of exposure to these substances on arterial phenotype and CV risk factor profile in young adulthood.
reference link :https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340100/
Source: European Society of Cardiology
