Unraveling Altered Brain Connectivity in Obesity: Implications for Food Craving and Cognitive Control


Obesity, a complex and multifaceted condition, has become a significant global health concern. As societies have transitioned towards sedentary lifestyles and diets high in processed and calorie-dense foods, the prevalence of obesity has risen dramatically.

While it’s well-known that obesity is influenced by a combination of genetic, environmental, and behavioral factors, the role of the brain’s reward and cognitive control systems in driving unhealthy eating behaviors has gained increasing attention.

A recent groundbreaking study sheds light on the intricate connections within the brain that might be contributing to the heightened reward response and impaired control over food consumption observed in individuals with obesity.

The Reward System and Altered Connectivity

Central to this study is the ventral tegmental area (VTA), a brain region situated within the midbrain that plays a pivotal role in motivation, reward processing, and the release of dopamine – a neurotransmitter associated with pleasure and reinforcement.

The researchers discovered that patients with obesity display distinct patterns of connectivity between the VTA and other brain regions, which sheds light on the neurological underpinnings of their heightened food cravings and altered cognitive control over eating.

For the first time, the study highlights that the VTA exhibits altered connectivity with specific brain regions in individuals with obesity. This altered connectivity involves hyper-connection with the visual ventral occipitotemporal cortex (vOTC), an area specialized in processing food-related images.

Interestingly, the VTA was also found to be hypo-connected with the left inferior frontal gyrus (IFG), a region associated with cognitive control and inhibitory processes. These connectivity patterns, previously unobserved, are intricately linked to the behavioral traits observed in obesity.

Craving and Cognitive Bias

One of the most intriguing findings of this study is the strong correlation between the strength of connectivity between the VTA and the vOTC with both food cravings and cognitive bias towards high-calorie foods. This suggests that the increased connectivity between these regions might enhance the significance of food-related visual stimuli, triggering a heightened craving for such foods. Furthermore, this craving is not solely about impulsivity; it is distinct from general impulsive behaviors and is not merely a consequence of immediate physiological needs like hunger.

Insights from Incentive Sensitization Theory

The study’s findings align remarkably well with the incentive sensitization theory, a framework initially applied to addiction. This theory posits that repeated exposure to rewarding stimuli leads to heightened responsiveness to cues associated with those rewards. In the context of obesity, the altered connectivity between the VTA and the vOTC could be interpreted as an indication of a strengthened cue-reward association, which potentially amplifies the allure of food-related cues and contributes to food cravings.

Neurofunctional Landscape

The researchers’ comprehensive analysis of the neurofunctional landscape highlights that the VTA has a diverse set of connections beyond its classic dopaminergic projections. These connections span areas involved in visual, emotional, and cognitive processing, underscoring the complexity of the brain’s reward circuitry.

Prefrontal Control and Cognitive Regulation

The study also underscores the importance of the prefrontal cortex (PFC) in regulating food cravings and inhibitory control. Patients with obesity demonstrated reduced connectivity between the VTA and the left IFG. This connectivity reduction correlated with increased food craving.

The lateral PFC, which forms part of the prefrontal-striatal circuit, has a role in cognitive regulation of craving. Individuals with stronger connectivity between the VTA and the lateral PFC exhibit better control over their cravings. This is consistent with the idea that cognitive reappraisal strategies, which involve engaging the PFC to downregulate the midbrain’s reward response, are linked to successful dietary self-regulation.

Potential Clinical Implications

The study’s insights could potentially revolutionize approaches to treating obesity. By understanding the altered connectivity patterns and their implications, researchers suggest that noninvasive brain neurostimulation techniques could be employed to modulate midbrain activity via the lateral PFC. This could offer a new avenue for interventions aimed at curbing food cravings and improving cognitive control over eating behaviors.

Limitations and Future Directions

While the study provides crucial insights, it does have limitations. The cross-sectional design restricts the ability to determine whether the observed connectivity patterns preexisted obesity or were induced by it. Additionally, the study focused on individuals with mild-to-moderate obesity, leaving room for future research to explore more severe cases.

Moreover, the absence of tailored behavioral measures to assess approach/reactivity to food cues and behavioral inhibition is a limitation, although the observed correlations with behavior and biases partially mitigate this concern.


In summary, this groundbreaking study uncovers novel insights into the brain connectivity patterns that contribute to heightened food cravings and diminished cognitive control in individuals with obesity. By revealing the altered connectivity between the VTA, visual processing regions, and the PFC, the study provides a framework to understand the neural basis of these behaviors.

These findings not only contribute to our understanding of obesity but also open doors to innovative interventions that target the brain’s reward and control systems to combat this global health challenge. As further research builds upon these findings, the potential for more effective obesity treatments comes into sharper focus.

reference link : https://onlinelibrary.wiley.com/doi/10.1002/oby.23834


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