The Delta’s Sub-Variant AY.29 is dominant in Japan

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The Delta AY.29 sub-variant was first identified by Japanese researchers from Niigata University and the Japanese National Institute of Genetics.

The Japanese study team reported a new sub-lineage of the SARS-CoV-2 Delta variant called AY.29, which has C5239T and T5514C mutations.

The study team had investigated the monthly trend of AY.29 in Japan within 11,954 Delta variants downloaded on September 3, 2021. Among the total Japanese Delta variants, the AY.29 sub-lineage accounted for 88.4%.

In terms of monthly changes, the sequences became predominant in June, and accounted for 93.2% and 94.2% of the reported sequences in July and August, respectively. Furthermore, the number of Delta variants imported from abroad during the Tokyo 2020 Olympics and Paralympics (held in August 2021) was extremely low.

Therefore, the epidemic of the new Delta variant is attributable to a newly occurring mutation in Japan.

Their study findings were published on a preprint server and are currently being peer reviewed. https://www.medrxiv.org/content/10.1101/2021.09.20.21263869v2

To date there is not much information available about the significance and characteristics nor the protein functions of the mutations C5239T and T5514C (ORF1ab: 56 V1750A) that distinguishes the Delta AY.29 sub-variant.

Data from the study sh ows that the Delta AY.29 sub-variant must have emerged around April 2021 in Japan but only became predominant around June and then became more potent and dangerous around August 2021, causing an increase of disease severity, hospitalizations and deaths.

Characteristic mutations of AY.29
geneamino acid
ORF1aA1306S
ORF1aV1750A
ORF1aP2046L
ORF1aP2287S
ORF1aV2930L
ORF1aT3255I
ORF1aT3646A
ORF1bP314L
ORF1bG662S
ORF1bP1000L
ORF1bA1918V
ST19R
ST95I
SG142D
SE156G
Sdel157/158
SL452R
ST478K
SD614G
SP681R
SD950N
ORF3aS26L
MI82T
ORF7aV82A
ORF7aT120I
ORF7bT40I
ORF8D119I
ORF8del120/121
ND63G
NR203M
NG215C
ND377Y

reference link : https://outbreak.info/situation-reports?pango=AY.29

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