Celastrol is a lead pharmacologic candidate to treat rheumatoid arthritis

0
334

Autoimmune diseases occur when the immune system attacks healthy cells in the body, causing inflammation and tissue damage. There are currently no cures for autoimmune diseases, and existing treatments often have severe side effects. Therefore, there is a significant need for new therapies that can safely and effectively treat autoimmune diseases.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints, causing pain, stiffness, and inflammation. There is currently no cure for RA, but there are various treatments that can help manage symptoms, slow disease progression, and improve quality of life. In this article, we will discuss the different types of treatments available for RA.

  1. Medications: There are several types of medications used to treat RA, including:
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs, such as ibuprofen and naproxen, can help relieve pain and reduce inflammation.
  • Disease-modifying antirheumatic drugs (DMARDs): DMARDs, such as methotrexate and sulfasalazine, are used to slow down the progression of RA and prevent joint damage.
  • Biologic drugs: Biologics, such as adalimumab and etanercept, are a newer class of medications that target specific molecules in the immune system to reduce inflammation.
  • Corticosteroids: Corticosteroids, such as prednisone, can be used to reduce inflammation and suppress the immune system.
  1. Physical therapy: Physical therapy can help improve flexibility, strength, and range of motion in the affected joints. A physical therapist can also teach patients exercises to improve posture and reduce joint pain.
  2. Occupational therapy: An occupational therapist can help patients find ways to perform daily tasks without causing pain or worsening joint damage. They may also recommend assistive devices, such as braces or splints, to support the affected joints.
  3. Surgery: In severe cases of RA, surgery may be necessary to replace damaged joints. Joint replacement surgery involves removing the damaged joint and replacing it with an artificial joint.
  4. Lifestyle changes: Making certain lifestyle changes can help manage RA symptoms and improve overall health. These include:
  • Eating a healthy diet: A balanced diet can help reduce inflammation and provide essential nutrients for joint health.
  • Exercise regularly: Regular exercise can help improve joint function, reduce pain, and prevent joint damage.
  • Quit smoking: Smoking can worsen RA symptoms and increase the risk of complications.
  • Manage stress: Stress can worsen RA symptoms, so finding ways to manage stress, such as meditation or yoga, can be helpful.

In a recent study published in Science Immunology, researchers found that celastrol, a compound derived from a medicinal plant, can suppress humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.

Humoral immunity refers to the portion of the immune system that produces antibodies to fight against pathogens. However, in autoimmune diseases, the immune system produces antibodies that attack healthy cells in the body. Therefore, suppressing humoral immune responses is a potential strategy for treating autoimmune diseases.

Celastrol is a compound derived from the roots of Tripterygium wilfordii, a medicinal plant used in traditional Chinese medicine. Celastrol has been found to have anti-inflammatory, antioxidant, and anticancer properties. Previous studies have also suggested that celastrol can modulate the immune system.

In this study, the researchers investigated the effects of celastrol on humoral immune responses and autoimmunity using both in vitro and in vivo experiments. They found that celastrol significantly reduced the production of antibodies in B cells, a type of immune cell that produces antibodies. Celastrol also inhibited the activation of T cells, another type of immune cell that plays a key role in autoimmune diseases.

The researchers also tested the effects of celastrol on a mouse model of systemic lupus erythematosus (SLE), an autoimmune disease characterized by the production of autoantibodies that attack various organs in the body. They found that celastrol treatment significantly reduced the levels of autoantibodies and improved the survival of the mice.

To understand the mechanism by which celastrol suppresses humoral immune responses, the researchers performed a series of experiments and found that celastrol targets the COMMD3/8 complex, a protein complex that regulates the stability and activity of the NF-κB signaling pathway, a key pathway involved in immune responses. Celastrol binds to the COMMD3/8 complex and disrupts its interaction with NF-κB, thereby inhibiting the activation of the pathway and reducing the production of antibodies.

Overall, these findings suggest that celastrol has potential as a therapeutic agent for autoimmune diseases. Celastrol’s ability to suppress humoral immune responses and target the COMMD3/8 complex may provide a new strategy for the treatment of autoimmune diseases. Future studies will be needed to evaluate the safety and efficacy of celastrol in human clinical trials. However, this study provides a promising starting point for the development of new therapies for autoimmune diseases.

… further information

Tripterygium wilfordii, also known as Thunder God Vine, is a plant that has been used for centuries in traditional Chinese medicine to treat a variety of ailments, including rheumatoid arthritis (RA). The plant contains several biologically active compounds, including celastrol, triptolide, and wilforlide, which have been shown to have anti-inflammatory and immunosuppressive effects.

In recent years, there has been growing interest in using Tripterygium wilfordii as a natural supplement to treat RA. Here’s what the current research says about the potential benefits of Tripterygium wilfordii for RA:

  • Reducing inflammation: Tripterygium wilfordii contains several compounds that have been shown to have anti-inflammatory effects. For example, celastrol has been found to inhibit the production of pro-inflammatory cytokines, such as TNF-alpha and IL-6, which play a key role in RA.
  • Improving joint function: In a study published in the journal Arthritis Research & Therapy, RA patients who took Tripterygium wilfordii supplements for 24 weeks experienced a significant improvement in joint function compared to those who took a placebo.
  • Reducing pain: Another study published in the same journal found that RA patients who took Tripterygium wilfordii supplements for 12 weeks reported a significant reduction in pain compared to those who took a placebo.
  • Modulating the immune system: Tripterygium wilfordii contains compounds that have been shown to modulate the immune system, which may be helpful for RA. For example, triptolide has been found to suppress the production of antibodies and inhibit the activation of T cells, both of which play a key role in RA.

It’s important to note that while Tripterygium wilfordii has shown promise as a natural supplement for RA, it can also have serious side effects. For example, high doses of the plant can cause liver damage, gastrointestinal problems, and other adverse effects. Therefore, it’s important to work with a healthcare provider to determine the appropriate dose and to monitor for potential side effects.

Here are some of the key chemical components and properties of Tripterygium wilfordii:

  1. Terpenoids: Tripterygium wilfordii contains several terpenoids, including triptolide and celastrol, which are the most extensively studied compounds in the plant. These terpenoids have been shown to have anti-inflammatory, immunosuppressive, and anti-cancer effects.
  • Triptolide: This compound has been shown to inhibit the production of pro-inflammatory cytokines, such as TNF-alpha and IL-6, which play a key role in rheumatoid arthritis. It has also been found to suppress the activation of T cells, which are involved in the immune response.
  • Celastrol: This compound has been found to have antioxidant, anti-inflammatory, and anti-cancer effects. It has been shown to inhibit the production of pro-inflammatory cytokines and to reduce inflammation in animal models of rheumatoid arthritis.
  1. Diterpenoids: Tripterygium wilfordii also contains several diterpenoids, including wilforlide A and B, which have been shown to have anti-inflammatory and immunosuppressive effects.
  • Wilforlide A: This compound has been found to inhibit the production of pro-inflammatory cytokines and to reduce inflammation in animal models of rheumatoid arthritis.
  1. Triterpenoids: Tripterygium wilfordii contains several triterpenoids, including triptophenolide, which has been shown to have anti-cancer effects.
  2. Alkaloids: Tripterygium wilfordii contains several alkaloids, including isotriptophenolide, which has been shown to have anti-cancer effects.

The chemical components of Tripterygium wilfordii have been extensively studied for their potential therapeutic uses. In addition to their effects on rheumatoid arthritis and cancer, these compounds have also been found to have neuroprotective, cardioprotective, and hepatoprotective effects. However, it’s important to note that high doses of Tripterygium wilfordii can have serious side effects, including liver toxicity, gastrointestinal problems, and infertility. Therefore, it’s important to work with a healthcare provider to determine the appropriate dose and to monitor for potential side effects when using Tripterygium wilfordii supplements.

reference link : https://www.science.org/doi/10.1126/sciimmunol.adc9324

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Questo sito usa Akismet per ridurre lo spam. Scopri come i tuoi dati vengono elaborati.