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Monthly Archives: Dicembre 2023

The Molecular Switch: Understanding SARS-CoV-2 Spike Protein’s Role in COVID-19

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The emergence of the novel coronavirus, SARS-CoV-2, in late 2019 led to a global pandemic, causing widespread illness and death on an unprecedented scale...

Exploring the Role of Extracellular Vesicles in SARS-CoV-2 Reactivation and Transmission

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SARS-CoV-2, identified as the causative agent of the 2019–2021 viral pneumonia outbreak, led to a wide range of clinical manifestations known as COVID-19. The...

Advancing Neuroinflammation-Directed Gene Therapy: Targeting Alzheimer’s Disease with Innovative Microglia Lipid Nanoparticles

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Neurodegenerative disorders, particularly Alzheimer's disease (AD), are often associated with neuroinflammation, a condition that is increasingly the focus of research and clinical efforts due...

Revolutionizing AI Hardware: Bridging the Gap with Brain-Inspired Technologies

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Artificial Intelligence (AI) is dramatically transforming industries, medicine, society, and education, heralding a new era of technological advancement. The core driver of this revolution...

Exploring the Role of Demyelination in Post-COVID Depression

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The outbreak of COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019 rapidly escalated into a global pandemic. By...

Studio dei benefici cognitivi dell’estratto di Wasabi (Eutrema japonicum) (6-MSITC) negli anziani sani

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Il declino cognitivo è un fenomeno ben consolidato associato all’invecchiamento, con gli anziani che spesso mostrano prestazioni cognitive inferiori rispetto alle loro controparti più...

Investigating the Cognitive Benefits of Wasabi (Eutrema japonicum) Extract (6-MSITC) in Healthy Older Adults

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Cognitive decline is a well-established phenomenon associated with aging, with older adults often exhibiting lower cognitive performances compared to their younger counterparts . This...

The persistent impact of SARS-CoV2 on the brain

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On May 5, 2023, the World Health Organization (WHO) officially declared the end to the COVID-19 pandemic. While this announcement marked a significant milestone,...

Advancements in Gene Therapy for Glaucoma: Targeting the Actin Cytoskeleton and Oxidative Stress

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Glaucoma, a leading cause of global visual loss, affects approximately 80 million individuals worldwide . The disease involves progressive damage to the optic nerve...

The Intricate Role of α5β1 Integrin in SARS-CoV-2 Spike-Mediated Infection and COVID-19 Pathogenesis

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, employs angiotensin-converting enzyme 2 (ACE2) as its cell entry receptor, akin to...

The Antiviral Potential of Cobicistat and Ritonavir Against SARS-CoV-2 Variants and Other Human Coronaviruses

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The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the urgent need for effective antiviral treatments. The Coronaviridae...

Exploring the Anti-Obesity Potential of Citrus sphaerocarpa Hexane Extract

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Obesity, a complex medical condition stemming from an imbalance between calorie intake and expenditure, affects a staggering number of individuals globally . In 2016,...

COVID-19: the Emergence and Growth of JN.1 Variant in the United States

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The landscape of the COVID-19 pandemic is ever-evolving, with new variants constantly emerging. One such variant that has recently come into focus is JN.1....

Long-Term Impact of SARS-CoV-2 Infection on Macrophages and Natural Killer Cells

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the ongoing global COVID-19 pandemic, exhibits a complex interaction with the host immune...

Identification and Characterization of a Novel Echarate Virus Variant Causing Acute Febrile Illness in...

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The genus Phlebovirus, belonging to the order Bunyavirales and family Phenuiviridae, comprises 66 species, globally distributed and transmitted by various vectors such as sandflies,...